Yang Lab Receives First NIH R01 Award
We are excited to share that the Yang Lab has received its first NIH R01 award from the National Heart, Lung, and Blood Institute (NHLBI)!
Posts by Year
2026
Yang Lab Receives UVA Accelerator Innovation Fund Award
The Yang Laboratory has been awarded the FY2027 Accelerator Innovation Fund (AIF) award to advance the development of first-in-class DELE1-targeting biologic...
A metabolite-bridged complex between SerRS and SIRT2 couples NAD⁺ metabolism to translation control
Qian Zhang, Huimin Zhang, Marscha Hirschi, Sheng Li, Gabriel C. Lander, Jie Yang*, Xiang-Lei Yang*
We are honored to receive support from the Owens Family Foundation
The Yang Lab has been awarded a three-year, $300,000 philanthropic research grant from the Owens Family Foundation to support studies of mitochondrial stress...
De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response
Rui Yang*, Kaiyuan Zheng*, McGuire Metts, Yiluo Wang, Danyan Yin, Kevin P Li, Agnieszka A Prazmowska, David F Kashatus, Brian Kuhlman, Jie Yang
Yang Lab undergraduate Xiaoyi Luo receives the UVA Russ and Nancy Grimes Undergraduate Summer Research Scholarship
Xiaoyi Luo, an undergraduate researcher in the Yang Lab, has been awarded the UVA Russ and Nancy Grimes Undergraduate Summer Research Scholarship
Yang Lab Receives UVA Cancer Center Pilot Awards
The Yang Lab recently received the UVA Cancer Center Collaborative Pilot Single-Component Award with Dr. Shangming Tang and the Neuro TRT Pilot Award with Dr...
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
Wenqian Chen, Gabriel C. Lander*, Jie Yang*
2025
De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response
Rui Yang*, Kaiyuan Zheng*, McGuire Metts, Yiluo Wang, Danyan Yin, Kevin P. Li, Agnieszka A. Prazmowska, David F. Kashatus, Brian Kuhlman, Jie Yang
Provisional patent filed for de novo designed DELE1 binders
The Yang Lab has filed a provisional patent application through UVA Licensing and Ventures Group for engineered DELE1 binders that target the mitochondrial s...
Yang Lab has received pilot awards from the UVA Comprehensive Cancer Center
We received the following pilot awards from the UVA Comprehensive Cancer Center in 2025: ACS-IRG Pilot Award, Cancer Biology Pilot Award, and Pediatric Pilot...
Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD+ metabolism
Qian Zhang, Huimin Zhang, Marscha Hirschi, Sheng Li, Gabriel C. Lander, Jie Yang*, Xiang-Lei Yang*
Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress
We recently published “Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum...
2024
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
We recently published “Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation” in bioRxiv.
The Yang Lab is hiring across all levels!
We have open positions for Postdoctoral scholars, PhD students, and Research technicians. Please check the “Join” section for more information.
Jie is featured by the Thermo Fisher Cryo-EM webinar series
Jie talked about the imapct of Cryo-EM in gaining mechanistic insights into protein targets that are important in health and disease.
2023
DELE1 oligomerization promotes integrated stress response activation
We recently published “DELE1 oligomerization promotes integrated stress response activation” in Nature structural & molecular biology.
PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain
We recently published “PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain” in Genes & Diseases.
2022
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements
We recently published “Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements” in Journal of Bio...
2020
Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
We recently published “Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage” in ...
2019
Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
We recently published “Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomeriza...
2018
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
We recently published “Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis” in Science immunol...
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
We recently published “Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor” in Proc...
Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition
We recently published “Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition” in Structure.
2017
Live-cell visualization of gasdermin D-driven pyroptotic cell death
We recently published “Live-cell visualization of gasdermin D-driven pyroptotic cell death” in Journal of Biological Chemistry.
2016
Post-translational regulation of inflammasomes
We recently published “Post-translational regulation of inflammasomes” in Cellular & Molecular Immunology.