The Yang Lab Receives the ACS-IRG Pilot Grant! (2025–2026)
We are excited to share that the Yang Lab has been awarded the 2025–2026 ACS Institutional Research Grant (ACS-IRG) to support our pilot project on mitochond...
Our group is interested in studying the mechanisms by which proteins execute their biological functions at the molecular level. To achieve this, we use an array of interdisciplinary methodologies to examine the properties of protein molecules both in vitro and within cellular contexts. Central to our approach is the utilization of cryo-electron microscopy (cryo-EM) to determine the high-resolution structures of protein complexes, thereby revealing their conformational landscapes and interactive details. Complementarily, we use biochemical and cellular assays to substantiate the functional relevance of our cryo-EM structures, providing structure-guided mechanistic insights into the proteins under study. Currently, our primary focus lies in the structural and functional characterization of proteins integral to cellular stress sensing and response. Another branch of our research endeavors is to translate the mechanistic insights obtained into the realm of drug development. Our objective is to develop therapeutic agents, including chemical compounds, peptide inhibitors, de novo designed proteins, and antibodies, aimed at modulating the function of proteins involved in stress-response signaling pathways. This research holds profound implications for the treatment of a myriad of human diseases, including neurodegeneration, cancer, and cardiovascular disorders.
We are excited to share that the Yang Lab has been awarded the 2025–2026 ACS Institutional Research Grant (ACS-IRG) to support our pilot project on mitochond...
We recently published “Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation” in bioRxiv.
We have open positions for Postdoctoral scholars, PhD students, and Research technicians. Please check the “Join” section for more information.
Jie talked about the imapct of Cryo-EM in gaining mechanistic insights into protein targets that are important in health and disease.