Xiaoyi Luo, an undergraduate researcher in the Yang Lab, has been awarded the UVA Russ and Nancy Grimes Undergraduate Summer Research Scholarship
The Yang Lab recently received the UVA Cancer Center Collaborative Pilot Single-Component Award with Dr. Shangming Tang and the Neuro TRT Pilot Award with Dr...
Wenqian Chen, Gabriel C. Lander*, Jie Yang*
Rui Yang*, Kaiyuan Zheng*, McGuire Metts, Yiluo Wang, Danyan Yin, Kevin P. Li, Agnieszka A. Prazmowska, David F. Kashatus, Brian Kuhlman, Jie Yang
The Yang Lab has filed a provisional patent application through UVA Licensing and Ventures Group for engineered DELE1 binders that target the mitochondrial s...
We received the following pilot awards from the UVA Comprehensive Cancer Center in 2025: ACS-IRG Pilot Award, Cancer Biology Pilot Award, and Pediatric Pilot...
Qian Zhang, Huimin Zhang, Marscha Hirschi, Sheng Li, Gabriel C. Lander, Jie Yang*, Xiang-Lei Yang*
We recently published “Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum...
We recently published “Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation” in bioRxiv.
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Jie talked about the imapct of Cryo-EM in gaining mechanistic insights into protein targets that are important in health and disease.
We recently published “DELE1 oligomerization promotes integrated stress response activation” in Nature structural & molecular biology.
We recently published “PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain” in Genes & Diseases.
We recently published “Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements” in Journal of Bio...
We recently published “Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage” in ...
We recently published “Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomeriza...
We recently published “Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis” in Science immunol...
We recently published “Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor” in Proc...
We recently published “Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition” in Structure.
We recently published “Live-cell visualization of gasdermin D-driven pyroptotic cell death” in Journal of Biological Chemistry.
We recently published “Post-translational regulation of inflammasomes” in Cellular & Molecular Immunology.