The human ClpXP complex (hClpXP) orchestrates mitochondrial protein quality control through targeted degradation of misfolded and unnecessary proteins. While...
We recently published “Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD+ metabolism” in bioRxiv.
We recently published “Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum...
We are excited to share that the Yang Lab has been awarded the 2025–2026 ACS Institutional Research Grant (ACS-IRG) to support our pilot project on mitochond...
We recently published “Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation” in bioRxiv.
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Jie talked about the imapct of Cryo-EM in gaining mechanistic insights into protein targets that are important in health and disease.
We recently published “DELE1 oligomerization promotes integrated stress response activation” in Nature structural & molecular biology.
We recently published “PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain” in Genes & Diseases.
We recently published “Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements” in Journal of Bio...
We recently published “Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage” in ...
We recently published “Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomeriza...
We recently published “Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis” in Science immunol...
We recently published “Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor” in Proc...
We recently published “Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition” in Structure.
We recently published “Live-cell visualization of gasdermin D-driven pyroptotic cell death” in Journal of Biological Chemistry.
We recently published “Post-translational regulation of inflammasomes” in Cellular & Molecular Immunology.