Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
We recently published “Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation” in bioRxiv.
Posts by Year
2024
The Yang Lab is hiring across all levels!
We have open positions for Postdoctoral scholars, PhD students, and Research technicians. Please check the “Join” section for more information.
The Yang Lab Website is officially online!!!
We’re excited to launch the Yang Lab today! Many thanks to Weiyi Tang and Lauren Alexandrescu for their technical support!
Jie is featured by the Thermo Fisher Cryo-EM webinar series
Jie talked about the imapct of Cryo-EM in gaining mechanistic insights into protein targets that are important in health and disease.
2023
DELE1 oligomerization promotes integrated stress response activation
We recently published “DELE1 oligomerization promotes integrated stress response activation” in Nature structural & molecular biology.
PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain
We recently published “PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain” in Genes & Diseases.
2022
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements
We recently published “Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements” in Journal of Bio...
2020
Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
We recently published “Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage” in ...
2019
Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
We recently published “Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomeriza...
2018
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
We recently published “Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis” in Science immunol...
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
We recently published “Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor” in Proc...
Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition
We recently published “Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition” in Structure.
2017
Live-cell visualization of gasdermin D-driven pyroptotic cell death
We recently published “Live-cell visualization of gasdermin D-driven pyroptotic cell death” in Journal of Biological Chemistry.
2016
Post-translational regulation of inflammasomes
We recently published “Post-translational regulation of inflammasomes” in Cellular & Molecular Immunology.