Publications
Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD+ metabolism
Qian Zhang, Huimin Zhang, Marscha Hirschi, Sheng Li, Gabriel C. Lander, Jie Yang*, and Xiang-Lei Yang*
Published in bioRxiv.
Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress
Yue Dou, Danny Qiu, Vivien Li, Maja E. Wierzbińska, Gregory R. Keele, Wenpeng Liu, Jie Yang, Joao A. Paulo, Ling Qi, and Tian Zhang
Published in bioRxiv.
Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
Wenqian Chen, Jie Yang, and Gabriel C Lander
Published in bioRxiv.
DELE1 oligomerization promotes integrated stress response activation
Jie Yang, Kelsey R Baron, Daniel E Pride, Anette Schneemann, Xiaoyan Guo, Wenqian Chen, Albert S Song, Giovanni Aviles, Martin Kampmann, R Luke Wiseman, and Gabriel C Lander
Published in Nature structural & molecular biology.
PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain
Yamu Li, Zhonghua Liu, Yiqing Zhao, Jie Yang, Tsan Sam Xiao, Ronald A Conlon, and Zhenghe Wang
Published in Genes & Diseases.
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements
Jie Yang, Albert S Song, R Luke Wiseman, and Gabriel C Lander
Published in Journal of Biological Chemistry.
Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
Zhonghua Liu, Chuanping Wang, Jie Yang, Yinghua Chen, Bowen Zhou, Derek W Abbott, and Tsan Sam Xiao
Published in Immunity.
Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
Zhonghua Liu, Chuanping Wang, Jie Yang, Bowen Zhou, Rui Yang, Rajesh Ramachandran, Derek W Abbott, and Tsan Sam Xiao
Published in Immunity.
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C Kondolf, Bryan L Benson, Steven M Chirieleison, Alex Y Huang, George R. Dubyak, Tsan Sam Xiao, Xiaoxia Li, and Derek W Abbott
Published in Science immunology.
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W Abbott, and Tsan Sam Xiao
Published in Proceedings of the National Academy of Sciences.
Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition
Zhonghua Liu, Chuanping Wang, Joseph K Rathkey, Jie Yang, George R Dubyak, Derek W Abbott, and Tsan Sam Xiao
Published in Structure.
Live-cell visualization of gasdermin D-driven pyroptotic cell death
Joseph K Rathkey,, Bryan L Benson,, Steven M Chirieleison,, Jie Yang,, Tsan S Xiao,, George R Dubyak,, Alex Y Huang,, and Derek W Abbott
Published in Journal of Biological Chemistry.
Post-translational regulation of inflammasomes
Jie Yang, Zhonghua Liu, and Tsan Sam Xiao
Published in Cellular & Molecular Immunology.