Publications
DELE1 oligomerization promotes integrated stress response activation
Jie Yang, Kelsey R Baron, Daniel E Pride, Anette Schneemann, Xiaoyan Guo, Wenqian Chen, Albert S Song, Giovanni Aviles, Martin Kampmann, R Luke Wiseman, and Gabriel C Lander
Published in Nature structural & molecular biology.
PD-L1 expression is regulated by ATP-binding of the ERBB3 pseudokinase domain
Yamu Li, Zhonghua Liu, Yiqing Zhao, Jie Yang, Tsan Sam Xiao, Ronald A Conlon, and Zhenghe Wang
Published in Genes & Diseases.
Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements
Jie Yang, Albert S Song, R Luke Wiseman, and Gabriel C Lander
Published in Journal of Biological Chemistry.
Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
Zhonghua Liu, Chuanping Wang, Jie Yang, Yinghua Chen, Bowen Zhou, Derek W Abbott, and Tsan Sam Xiao
Published in Immunity.
Crystal structures of the full-length murine and human gasdermin D reveal mechanisms of autoinhibition, lipid binding, and oligomerization
Zhonghua Liu, Chuanping Wang, Jie Yang, Bowen Zhou, Rui Yang, Rajesh Ramachandran, Derek W Abbott, and Tsan Sam Xiao
Published in Immunity.
Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis
Joseph K. Rathkey, Junjie Zhao, Zhonghua Liu, Yinghua Chen, Jie Yang, Hannah C Kondolf, Bryan L Benson, Steven M Chirieleison, Alex Y Huang, George R. Dubyak, Tsan Sam Xiao, Xiaoxia Li, and Derek W Abbott
Published in Science immunology.
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
Jie Yang, Zhonghua Liu, Chuanping Wang, Rui Yang, Joseph K. Rathkey, Otis W. Pinkard, Wuxian Shi, Yinghua Chen, George R. Dubyak, Derek W Abbott, and Tsan Sam Xiao
Published in Proceedings of the National Academy of Sciences.
Structures of the gasdermin D C-terminal domains reveal mechanisms of autoinhibition
Zhonghua Liu, Chuanping Wang, Joseph K Rathkey, Jie Yang, George R Dubyak, Derek W Abbott, and Tsan Sam Xiao
Published in Structure.
Live-cell visualization of gasdermin D-driven pyroptotic cell death
Joseph K Rathkey,, Bryan L Benson,, Steven M Chirieleison,, Jie Yang,, Tsan S Xiao,, George R Dubyak,, Alex Y Huang,, and Derek W Abbott
Published in Journal of Biological Chemistry.
Post-translational regulation of inflammasomes
Jie Yang, Zhonghua Liu, and Tsan Sam Xiao
Published in Cellular & Molecular Immunology.