Jie Yang, Ph.D.

Assistant Professor, Department of Biochemistry and Molecular Genetics, School of Medicine

The Yang Lab has received pilot awards from the UVA Comprehensive Cancer Center

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We received the following pilot awards from the UVA Comprehensive Cancer Center in 2025: ACS-IRG Pilot Award, Cancer Biology Pilot Award, and Pediatric Pilot Award. We are grateful for the generous support from the Cancer Center and look forward to advancing the proposed studies.

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De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

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Rui Yang*, Kaiyuan Zheng*, McGuire Metts, Yiluo Wang, Danyan Yin, Kevin P. Li, Agnieszka A. Prazmowska, David F. Kashatus, Brian Kuhlman, Jie Yang

Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation

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Wenqian Chen, Gabriel C. Lander*, Jie Yang*

Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD+ metabolism

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Qian Zhang, Huimin Zhang, Marscha Hirschi, Sheng Li, Gabriel C. Lander, Jie Yang*, Xiang-Lei Yang*

Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress

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We recently published “Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum...

Jie Yang, Ph.D.

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De novo design of protein binders that target DELE1 to inhibit the mitochondrial stress response

Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation

Human SerRS/SIRT2 complex structure reveals cross regulation between translation and NAD+ metabolism

Integral Synthesis and Clearance Analysis via DIA (ISDia) Reveals Coordinated Protein Dynamics Regulation during Endoplasmic Reticulum Stress